COMPARATIVE STUDY OF LIPID PEROXIDATION AND ACTIVITY OF ANTIOXIDANTS INCLUDED INTO LIPOSOMES PRODUCED BY EXTRUSION AND SONIFICATION
Rinat A. Mukhamadiyarov, Igor G. Khaliulin, Alexey V. Veremeev, Irina Yu. Zhuravleva
Pages: 228-232
Published: 2 Jun 2014
Views: 3,148
Downloads: 795
Abstract: The properties of production and standardization of liposomes of complex composition by the methods of sonification and extrusion (through polycarbonate filters) have been studied. The study shows that both methods allow producing liposomes of different lipid composition with inclusion of various bioactive substances into lipid and intraliposomal phases. We also show that sonification causes the activation of lipid peroxidation and decreases the activity of biologically active substancesincluded into liposomes. Moreover the liposomes produced by sonification need standartization in particles size. The success of extrusion method depends on the correct choice of organic solvent, lipids and their hydration properties. It is shown that liposomes can be successfully separated from extra-liposomal substances using the method of gel-filtration.
Keywords: liposome production, liposome standartization, lipid peroxidation
Cite this article: Rinat A. Mukhamadiyarov, Igor G. Khaliulin, Alexey V. Veremeev, Irina Yu. Zhuravleva. COMPARATIVE STUDY OF LIPID PEROXIDATION AND ACTIVITY OF ANTIOXIDANTS INCLUDED INTO LIPOSOMES PRODUCED BY EXTRUSION AND SONIFICATION. Journal of International Scientific Publications: Materials, Methods & Technologies 8, 228-232 (2014). https://www.scientific-publications.net/en/article/1000166/
Back to the contents of the volume
© 2025 The Author(s). This is an open access article distributed under the terms of the
Creative Commons Attribution License https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This permission does not cover any third party copyrighted material which may appear in the work requested.
Disclaimer: The Publisher and/or the editor(s) are not responsible for the statements, opinions, and data contained in any published works. These are solely the views of the individual author(s) and contributor(s). The Publisher and/or the editor(s) disclaim any liability for injury to individuals or property arising from the ideas, methods, instructions, or products mentioned in the content.