A NOVEL SMALL-DIAMETER BIODEGRADABLE VASCULAR GRAFT BASED ON POLIOXYALCANOATES AND POLYCAPROLACTONE: PILOT STADY
Larisa V. Antonova, Alexey S. Golovkin, Andrey Y. Burago, Vera G. Matveeva, Elena A. Velikanova, Tatyana V. Glushkova, Georgy Y. Vasyukov, Olga L. Bar
Pages: 452-459 Published: 31 May 2015
Views: 1,750 Downloads: 722
Abstract: Copolymer tubular scaffolds based on polyhydroxybutirate with hydroxyvalerate /polycaprolactone (5% PBHV: 10% PCL) were fabricated by the electrospinning setup. Physical and mechanical properties of the copolymer were assessed as well as their biocompatibility in vitro. According to the preliminary results, tubular copolymer scaffolds demonstrated improved stress-strain properties, compared to the native vessels used for coronary artery bypass grafting. High porosity of the internal surface allowed to create a cellular monolayer from bone marrow-derived multipotent mesenchymal stromal cells and human umbilical vein endothelial cells in a short-term period. There was no decrease in cellular viability in the cell-surface interaction. 2 mm tubular copolymer scaffolds were implanted in the abdominal rat aortas. After a 12-months follow-up period, good graft patency and the absence of organism reactions towards the implanted grafts have been observed.