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Materials, Methods & Technologies, Volume 14, 2020

THE STUDY OF ANTIPHOSPHOLIPID SYNDROME IN ALBANIAN POPULATION
Anila Mitre, Katerina Pikuli
Pages: 247-256
Published: 12 Sep 2020
Views: 150
Downloads: 13
Abstract: Antiphospholipid antibodies (aPL) are a family of autoantibodies with specificity for negatively charged phospholipids, and for their complex to phospholipid binding proteins. Their presence is associated with arterial or venous thrombosis and recurrent pregnancy loss. A combination of genetics with environmental factors are involved in development of APS syndrome. Antiphospholipid syndrome is diagnosed in young to middle-aged adults and is more common in females. There are two broad categories of assays that are used to diagnose APS: coagulation assays which study the effect of LAC on the clotting time and immunological assays, mostly ELISAs to detect IgG and IgM antibodies against cardiolipin, fosfatidilserine and β2 glycoprotein I. For diagnosis of APS, at least one clinical criterion and one laboratory criteria (Sydney) should be present. From 2016-2019, 120 patients were evaluated with suspect diagnose: Antiphospholipid Syndrome and 94 cases are a control group which represent normal people who does not present health problems. The patients’ age varies from 6-60 years. Based on the comparison of the parameters between the control group and the positive individuals, a very large variation of the main values of aPL antibodies was observed in persons with this syndrome. Risk for clinical manifestations appears to be associated with moderate to high levels of these autoantibodies. The most affected individuals belong to the age group 21-45 years and female gender. In this study we came to the conclusion that none of the markers studied is a perfect indicator of Antiphospholipid Syndrome. Lupus anticoagulant is the most sensitive marker in the detection of syndrome and after that β2GPI IgM.
Keywords: antiphospholipid antibodies, recurrent pregnancy loss, venous and arterial thrombosis, lupus anticoagulant
Cite this article: Anila Mitre, Katerina Pikuli. THE STUDY OF ANTIPHOSPHOLIPID SYNDROME IN ALBANIAN POPULATION. Journal of International Scientific Publications: Materials, Methods & Technologies 14, 247-256 (2020). https://www.scientific-publications.net/en/article/1002067/
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