EVALUATION OF THE ESTROGENIC EFFECT OF POLYCHLORINATED BIPHENYLS WITH REGARD TO THEIR METABOLIC ACTIVATION BY APPLICATION OF IN SILICO TECHNOLOGIES
Milen P. Todorov
Strony: 520-526
Opublikowano: 1 Jun 2014
Wyświetlenia: 4,344
Pobrania: 894
Streszczenie: Hydroxylated polychlorinated biphenyls (OH-PCBs) major metabolites of PCBs, have been reported to present affinity to the estrogen receptor and induce receptor-mediated responses. The early identification of PCBs which may act as estrogen binders was investigated by making use of computational tools for chemical risk assessment. As an area of growing concern a strategy for development of such tools is one of the primary tasks of governmental and international organizations. In the current study the estrogenic potential of several PCBs is analyzed by using widely accepted and standardized computational program. The obtained results suggest that the system is equipped with scientific reliable modules for prediction of the estrogenic potential of diverse chemicals as well as robust machinery for adequate metabolism simulation.
Słowa kluczowe: estrogen receptor, qsar, polychlorinated biphenyls (pcbs), metabolic activation, in silicon tools
Cytowanie artykułu: Milen P. Todorov. EVALUATION OF THE ESTROGENIC EFFECT OF POLYCHLORINATED BIPHENYLS WITH REGARD TO THEIR METABOLIC ACTIVATION BY APPLICATION OF IN SILICO TECHNOLOGIES. Journal of International Scientific Publications: Ecology & Safety 8, 520-526 (2014). https://www.scientific-publications.net/en/article/1000125/
Powrót do spisu treści tomu
© 2026 The Author(s). This is an open access article distributed under the terms of the
Creative Commons Attribution License https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This permission does not cover any third party copyrighted material which may appear in the work requested.
Disclaimer: The Publisher and/or the editor(s) are not responsible for the statements, opinions, and data contained in any published works. These are solely the views of the individual author(s) and contributor(s). The Publisher and/or the editor(s) disclaim any liability for injury to individuals or property arising from the ideas, methods, instructions, or products mentioned in the content.
