ANALYSIS OF THE PANGENOME OF BACILLUS CEREUS AND ITS RELEVANCE IN FOOD SAFETY
José Carlos Parada Fabián, Ana Karen Álvarez Contreras, Iván Natividad Bonifacio, Marcos Francisco Hernández Robles, Carlos Ramón Vázquez Quiñones, Elsa Irma Quiñones Ramírez, Carlos Vázquez Salinas
Strony: 1-20
Otrzymano: 31 Jul 2025
Opublikowano: 29 Dec 2025
DOI: 10.62991/AF1996736071
Wyświetlenia: 574
Pobrania: 117
Streszczenie: The study of the pangenome of Bacillus cereus through the analysis of 135 complete and validated genomes provides insight into its genetic diversity and implications for food safety. The pangenome, composed of a core genome (shared by all strains) and an accessory genome (variable between strains), can be classified as open, demonstrating a high adaptive capacity due to the acquisition of genes through horizontal gene transfer. This analysis identifies key genes associated with virulence, such as those responsible for producing toxins (Nhe, Hbl, cereulide), spore formation, and biofilm production. These factors are fundamental for understanding the differential pathogenicity of strains and their persistence in food-related environments. Additionally, exclusive genes and those within the accessory genome reveal specific adaptations, such as resistance to extreme conditions or metabolic advantages for colonizing diverse niches. Phylogenomic analysis based on core genome genes enables the identification of clades and lineages associated with outbreaks of foodborne diseases. Moreover, the detection of antibiotic resistance genes and mobile genetic elements, such as plasmids and transposons, highlights the risk of resistance dissemination in food and clinical environments. These findings are essential for developing targeted control strategies, improving detection methods in the food industry, and mitigating risks associated with the contamination and transmission of B. cereus. The pangenomic approach integrates bioinformatics and microbiological analyses to advance the surveillance and control of this pathogen in the food chain, contributing to the protection of public health.
Słowa kluczowe: bacillus cereus, pangenome, virulence factors, antibiotic resistance, food safety
Cytowanie artykułu: José Carlos Parada Fabián, Ana Karen Álvarez Contreras, Iván Natividad Bonifacio, Marcos Francisco Hernández Robles, Carlos Ramón Vázquez Quiñones, Elsa Irma Quiñones Ramírez, Carlos Vázquez Salinas. ANALYSIS OF THE PANGENOME OF BACILLUS CEREUS AND ITS RELEVANCE IN FOOD SAFETY. Journal of International Scientific Publications: Agriculture & Food 13, 1-20 (2025). https://doi.org/10.62991/AF1996736071
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