SEARCH OF ANTITUMOUR MEDICAL DRUGS BY WAY OF CREATION OF NEW ANTIMETABOLITES OF PYRIMIDINES CHANGE – BIS-DERIVATIVES OF 5(6)- SUBSTITUTED URACILES AND THEIR ADDUCTS WITH BACTERIAL LECTINS
Elena V. Welchinskaya, Valeria V. Vilchinskaya
Strony: 355-361
Opublikowano: 1 Jan 2013
Wyświetlenia: 270
Pobrania: 26
Streszczenie: A new convenient method for the preparation of heterocyclic bis-adducts of 5(6)-substituted uraciles with ftorotan (1,1,1-threefluoro-2-bromo-2-chloroethane) is described. The reactions are catalyzed by the 18-crown-6-complex. The structure of synthesized compounds has been confirmed by data of elemental analysis, IR- and ІН-spectra. The new molecular complexes were created on the base of bacterial lectins and some of heterocyclic bis-adducts of 5(6)-substituted uraciles, which synthesized. The critical toxicity and antitumour activity of new bis-adducts, saprophytic stammes Bacillus genus (B. subtilis 668 IMV and B. polymyxa 102 KGU) extracellular lectins and their molecular complexes were studies. It was discovered that these substances apply to little and moderate toxic preparations and has an expression antitumour action on the tumours: Lymphosarcoma Plissa and Sarcoma 45. A strongly antitumour effect of bis-adduct of 5-fluorouracile, bacterial lectins and their molecular complexes (bis-adduct of 5-fluorouracile + B. subtilis 668 IMV or B. polymyxa 102 KGU) has been discovered: growth relaxation of the Lymphosarcoma Plissa tumour mass was 50,0 -75,3%, of the Sarcoma 45: 16,9-81,1%.
Słowa kluczowe: 5-fluorouracile, bacterial lectins, heterocyclic bis-adducts, antitumour effect
Cytowanie artykułu: Elena V. Welchinskaya, Valeria V. Vilchinskaya. SEARCH OF ANTITUMOUR MEDICAL DRUGS BY WAY OF CREATION OF NEW ANTIMETABOLITES OF PYRIMIDINES CHANGE – BIS-DERIVATIVES OF 5(6)- SUBSTITUTED URACILES AND THEIR ADDUCTS WITH BACTERIAL LECTINS. Journal of International Scientific Publications: Materials, Methods & Technologies 7, 355-361 (2013). https://www.scientific-publications.net/en/article/1003116/
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