LUMINISCENT LIPOSOME LABELING TECHNOLOGY WITH PKH-26 SOLUTION AND ABSORPTION AND DISTRIBUTION ASSESSMENT OF LIPID MULTILAMELLAR VESICLES AND SMALL LIPOSOMES IN LIVER FOLLOWING INTRAVENOUS ADMINISTRATION
Rinat A. Mukhamadiyarov, Sergey F. Zinchuk, Mariya A. Kruch, Olga D. Sidorova
Pagini: 381-391
Publicat: 1 Jan 2012
Vizualizări: 242
Descărcări: 24
Rezumat: This study examined the possibility to form liposomal compositions containing PKH-26 fluorescent dye and to use those compositions in order to assess absorption and tissue distribution of the liposomes in rat liver. Liposomal compositions consisted of egg lecithin and cholesterol (Sigma) in a 7:5 ratio, respectively. The dye was incorporated into the lipid layer while preparing multilamellar vesicles with the extruder. The obtained labeled liposomal compositions allowed to quantitatively assess how the vesicles are absorbed by the liver and visualize the dye distribution in different liver cells. The study presents the data on the absorption and distribution of the dye in the liver, according to the size of the lipid vesicles, 1, 2 and 24 hours after the intravenous administartion.
Cuvinte cheie: luminescent labeling, absorption of the liposomes, visualization of the liposomes
Citează acest articol: Rinat A. Mukhamadiyarov, Sergey F. Zinchuk, Mariya A. Kruch, Olga D. Sidorova. LUMINISCENT LIPOSOME LABELING TECHNOLOGY WITH PKH-26 SOLUTION AND ABSORPTION AND DISTRIBUTION ASSESSMENT OF LIPID MULTILAMELLAR VESICLES AND SMALL LIPOSOMES IN LIVER FOLLOWING INTRAVENOUS ADMINISTRATION. Journal of International Scientific Publications: Materials, Methods & Technologies 6, 381-391 (2012). https://www.scientific-publications.net/en/article/1003222/
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