SYNTHESIS OF 1-BIPHENYL 1,2,3,4-TETRAHYDROISOQUINOLINE
Dimo Aladjov, Stoyanka Nikolova, Iliyan Ivanov
Pagini: 138-142
Publicat: 1 Jan 2011
Vizualizări: 81
Rezumat: The biological activity of isoquinoline derivatives, as analogues of various drugs, has provided great deal of interest for the synthesis of new compounds. An application of Bischler-Napieralski reaction st for the synthesis of new 1,2,3,4-tetrahydroisoquinolines with biphenyl substitutent on the 1 position, is described. The required for this purpose amides would arise from reaction of aminoacetaldehyd- dimethylacetal with veratrole (1,2-dimetoxybenzene) in polyphosphoric acid, followed by acylation of obtained amines with different acid chlorides or sulfochlorides. Variety of reaction conditions – acidity of milieu, temperature and reaction time, were used for optimization the conditions for the final cyclization stage. Along with the synthetic studies, structure-activity relationships will be sought (SAR and QSAR study of the compounds). Discovery of bioactivity can eventually lead to development of new therapeutic compounds. There is a possibility for application of the results in the pharmaceutical sector, should the biological properties of the obtained compounds be satisfactory for development of new drugs. The synthetic methodology which is expected to be developed will positively find future applications in the academic/research/ pharmaceutical sector.
Cuvinte cheie: dihydroorotat dehydrogenase inhibitors, biphenyl substituent, tetrahydroisoquinolines
Citează acest articol: Dimo Aladjov, Stoyanka Nikolova, Iliyan Ivanov. SYNTHESIS OF 1-BIPHENYL 1,2,3,4-TETRAHYDROISOQUINOLINE. Journal of International Scientific Publications: Materials, Methods & Technologies 5, 138-142 (2011). https://www.scientific-publications.net/en/article/1003291/
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