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Materials, Methods & Technologies, Volume 8, 2014

SYNTHESIS OF 1,4-DISUBSTITUTED ISOQUINOLINES AS CHERYLLINE DERIVATIVES
Stanimir P. Manolov, Stoyanka N. Atanasova, Iliyan I. Ivanov
Pages: 272-277
Published: 2 Jun 2014
Views: 1392
Downloads: 700
Abstract: Synthetic studies of aryl-l,2,3,4-tetrahydroisoquinolines have attracted much attention from the synthetic community owing to the potential biological activities of this class of compounds and their increasing medicinal interest. The alkaloid cherylline is a naturally occurring optically active, 4-aryl-1,2,3,4- tetrahydroisoquinoline alkaloid, isolated from Crinum Powellii, Amaryllidaceae plant. There are many ways for cherylline synthesis. An application of Bischler-Napieralski reaction for the synthesis of new 1,4-disubstituted- 1,2,3,4- tetrahydroisoquinolines as cherylline derivatives, is described.
Keywords: cherylline, 1,4-disubstituted-tetrahydroisoquinolines, bischler-napieralski reaction
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