SYNTHESIS OF 1,4-DISUBSTITUTED ISOQUINOLINES AS CHERYLLINE DERIVATIVES
Published: 2 Jun 2014
Abstract: Synthetic studies of aryl-l,2,3,4-tetrahydroisoquinolines have attracted much attention from the synthetic community owing to the potential biological activities of this class of compounds and their increasing medicinal interest. The alkaloid cherylline is a naturally occurring optically active, 4-aryl-1,2,3,4- tetrahydroisoquinoline alkaloid, isolated from Crinum Powellii, Amaryllidaceae plant. There are many ways for cherylline synthesis. An application of Bischler-Napieralski reaction for the synthesis of new 1,4-disubstituted- 1,2,3,4- tetrahydroisoquinolines as cherylline derivatives, is described.
Keywords: cherylline, 1,4-disubstituted-tetrahydroisoquinolines, bischler-napieralski reaction
Cite this article: Stanimir P. Manolov, Stoyanka N. Atanasova, Iliyan I. Ivanov. SYNTHESIS OF 1,4-DISUBSTITUTED ISOQUINOLINES AS CHERYLLINE DERIVATIVES. Journal of International Scientific Publications: Materials, Methods & Technologies 8, 272-277 (2014). https://www.scientific-publications.net/en/article/1000172/
Download full text
Back to the contents of the volume
© 2023 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/
, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This permission does not cover any third party copyrighted material which may appear in the work requested.