SYNTHESIS OF 1,4-DISUBSTITUTED ISOQUINOLINES AS CHERYLLINE DERIVATIVES
Stanimir P. Manolov, Stoyanka N. Atanasova, Iliyan I. Ivanov
Pages: 272-277
Published: 2 Jun 2014
Views: 3,032
Downloads: 1,027
Abstract: Synthetic studies of aryl-l,2,3,4-tetrahydroisoquinolines have attracted much attention from the synthetic community owing to the potential biological activities of this class of compounds and their increasing medicinal interest. The alkaloid cherylline is a naturally occurring optically active, 4-aryl-1,2,3,4- tetrahydroisoquinoline alkaloid, isolated from Crinum Powellii, Amaryllidaceae plant. There are many ways for cherylline synthesis. An application of Bischler-Napieralski reaction for the synthesis of new 1,4-disubstituted- 1,2,3,4- tetrahydroisoquinolines as cherylline derivatives, is described.
Keywords: cherylline, 1,4-disubstituted-tetrahydroisoquinolines, bischler-napieralski reaction
Cite this article: Stanimir P. Manolov, Stoyanka N. Atanasova, Iliyan I. Ivanov. SYNTHESIS OF 1,4-DISUBSTITUTED ISOQUINOLINES AS CHERYLLINE DERIVATIVES. Journal of International Scientific Publications: Materials, Methods & Technologies 8, 272-277 (2014). https://www.scientific-publications.net/en/article/1000172/
Back to the contents of the volume
© 2025 The Author(s). This is an open access article distributed under the terms of the
Creative Commons Attribution License https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This permission does not cover any third party copyrighted material which may appear in the work requested.
Disclaimer: The Publisher and/or the editor(s) are not responsible for the statements, opinions, and data contained in any published works. These are solely the views of the individual author(s) and contributor(s). The Publisher and/or the editor(s) disclaim any liability for injury to individuals or property arising from the ideas, methods, instructions, or products mentioned in the content.