Pages: 365-374 Published: 23 May 2015
Views: 2,372 Downloads: 954
Abstract: Emamectin benzoate (Proclaim®) is a biopesticide derivative of the avermectins developed for the control of insect pests. In the present study, the ameliorating effect of vitamin C was examined histologically and biochemically in testicle tissue of male Wistar rats, Rattus norvegicus, exposed to emamectin benzoate (EMB). Male rats (n=21) were allocated into 3 groups of seven each: Group I served as control rats; Group II was given daily EMB at dose of 10 mg/kg b.w. by gavage. Group III received EMB (10 mg/kg b.w.) and were co administered with vitamin C intraperitoneally (200 mg/kg/day) during 28 days. Rats were followed-up for an additional 14 day-period to detect delayed occurrence or persistence of toxic effects.
Keywords: emamectin benzoate, testes, vitamin c, histopathology, uplc-ms/ms, rat