SUBACUTE TOXICOLOGICAL EFFECTS OF EMAMECTINE BENZOATE ON WISTAR RAT TESTES: HISTOPATHOLOGICAL CHANGES, DETERMINATION OF EMAMECTIN BENZOATE RESIDUES BY UPLC-MS/MS AND PROTECTIVE EFFECT OF VITAMIN C
Published: 23 May 2015
Abstract: Emamectin benzoate (Proclaim®) is a biopesticide derivative of the avermectins developed for the control of insect pests. In the present study, the ameliorating effect of vitamin C was examined histologically and biochemically in testicle tissue of male Wistar rats, Rattus norvegicus, exposed to emamectin benzoate (EMB). Male rats (n=21) were allocated into 3 groups of seven each: Group I served as control rats; Group II was given daily EMB at dose of 10 mg/kg b.w. by gavage. Group III received EMB (10 mg/kg b.w.) and were co administered with vitamin C intraperitoneally (200 mg/kg/day) during 28 days. Rats were followed-up for an additional 14 day-period to detect delayed occurrence or persistence of toxic effects.
Keywords: emamectin benzoate, testes, vitamin c, histopathology, uplc-ms/ms, rat
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