THE EFFECTS OF RADIO-FREQUENCY PLASMA DISCHARGE ON SURFACE PROPERTIES AND BIOCOMPATIBILITY OF POLYCAPROLACTONE SCAFFOLDS
Published: 31 May 2015
Abstract: The study is aimed at the assessment of surface modification of bioresorbable polymeric material (polycaprolactone (PLC) by radio-frequency magnetron discharge plasma with hydroxyapatite target sputtering. Plasma surface modification increases its roughness, the surface free energy, hydrophilicity and enhances the growth of PCL crystallites. An increase in plasma exposure times (30, 60, 150 s) increases the saturation of the polymer surface with sputtering target ions (calcium, phosphorus). The effects of plasma exposure times on the behavior of multipotent mesenchymal stem cells (MMSCs) were assessed. Plasma modification of PCL stimulates the attachment and subsequent proliferation of MMSCs, thus a 60-second plasma exposure period is considered to be an optimal modification mode. This type of plasma modification does not affect cell viability (apoptosis, necrosis). Thus, the radio-frequency magnetron sputtering of a hydroxyapatite target appears to be a promosing method to modify bioresorbable polymer surfaces (PCL) in tissue engineering.
Keywords: surface modification, polycaprolactone, roughness, free surface energy, hydrophilicity, biocompatibility
Download full text
Back to the contents of the volume
© 2018 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/
, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This permission does not cover any third party copyrighted material which may appear in the work requested.