PREPARATION AND CHARACTERIZATION OF BRUSHITE CEMENTS BASED ON AMORPHOUS CALCIUM PHOSPHATE AND CARBOXYLIC ACIDS
Published: 29 Jul 2017
Abstract: Three series of calcium phosphate brushite cements based on double doped amorphous calcium phosphate ((Mg,Zn)-ACP) and carboxylic acid (citric, tartaric or lactic) were prepared. The effect of the acid used, as well as that of the solid to liquid ratio on the transformation of (Mg,Zn)-ACP to brushite phase and on the forming characteristics and setting times were studied. Two types of in vitro tests of the cement molds were performed – long-term behavior of the molds in simulated body fluid (SBFc) and cell test with three types of cell cultures. The cement mold based on (Mg,Zn)-ACP and tartaric acid was found to display the best forming characteristics, the highest stability and the lowest cytotoxicity.
Keywords: brushite cements, amorphous calcium phosphate, carboxylic acids, cell viability
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