International Scientific Publications
© 2020 Science Events Ltd
Terms of Use  ·  Privacy Policy
Choose language English French Russian Bulgarian
Conference room
Materials, Methods & Technologies 2021, 23rd International Conference
19-22 August, Burgas, Bulgaria
Call for Papers

Materials, Methods & Technologies, Volume 11, 2017

N. Miyoshi, K. Karaya, I. Shimada, H. Tanaka, Y. Sakurai, M. Suzuki, A. Zaitsev, V. Ol‘shevskaya, G. Rychkov, K. Ono, V. Kalinin, A. Shtil
Pages: 395-402
Published: 29 Jul 2017
Views: 990
Downloads: 291
Abstract: Physical methods in antitumor treatment are frequently used in combination (simultaneous or sequential) to achieve maximal effect. Therefore, the compound capable of sensitizing tumor cells to different types of energy (light, ionizing X-rays, thermal neutrons) would be applicable in more than one therapeutic modality. We synthesized a novel fluorinated boron-containing chlorin derivative {5,10,15,20-tetrakis[4-(1-carba-closo-dodecaboran-1-yl)tetrafluorophenyl]-17,18-dihydroporphyrin)] tetrasodium (Compound-B). In this compound the boron atoms are represented by boron-10. Compound-B showed a good water solubility and cytoplasmic accumulation, as well as low-to null dark cytotoxicity. Compound-B potently (at low M concentrations) sensitized the transplanted C6 glial tumor cells (a BALB-c-nu/nu murine model) to PDT and BNCT. Importantly, Compound-B also increased the efficacy of proton or carbon therapy. These results provide evidence that structural optimizations of known chemical classes may confer valuable characteristics to compounds initially designated for one particular therapeutic modality.
Keywords: combination therapy, tumor model, radiological regions
Download full text

Back to the contents of the volume
By using this site you agree to our Privacy Policy and Terms of Use. We use cookies, including for analytics, personalisation, and ads.