VERTIMEC® MEDIATES PLASMA BIOCHEMICAL CHANGES AND HISTOPATHOLOGICAL DAMAGE IN THE KIDNEY OF RATS (RATTUS NORVEGICUS)
Published: 18 Dec 2017
Abstract: Abamectin (ABA) is a biopesticide extracted from the actinomycete soil microorganism Streptomyces avermitilis, and the active ingredient of vertimec®, a commercial formulation commonly used pesticide in Algeria. Vertimec® was administered orally to male and female rats at dose of 2,13 mg/kg/day. The duration of the treatment was 28 days and the duration of the study was 42 days. Plasma samples were used to determine the biochemical parameters (glucose, urea, creatinine, uric acid).The residual concentrations of abamectine B1a were estimated in plasma and kidney of rats using UPLC MS/MS method. Treatment with ABA affects the mean weight of most organs (kidney, liver, heart, thymus, and adrenal glands). Moreover significant change in glucose, urea, creatinine and uric acid levels intra plasma after 14 and 28 days were observed. All experimental animals showed time-dependent presence of B1a residues in the plasma samples at 14 and 28 days. B1a residues in the kidney were detected in male and female rats at the end of the experiment 42days. Light microscopic observations revealed variable signs of nephrotoxicity in the ABA group, which were represented by alteration of normal renal architecture, inflammatory cell infiltration congestion and dilation of proximal and distal tubules. In conclusion, our investigations show that exposure vertimec® affects the reproductive and kidney function in male and female rats.
Keywords: abamectin, biochemical parameters, kidney histopathology, rat
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