IN VITRO AND IN SILICO BIOLOGICAL ACTIVITY OF NEW IBUPROFEN HYBRIDS
Stanimir P. Manolov, Iliyan I. Ivanov, Dimitar G. Bojilov
Pages: 202-211
Published: 23 Sep 2021
Views: 882
Downloads: 81
Abstract: Herein we report the biological evaluation of new hybrids of 1,2,3,4-tetrahydroisoquinoline with ibuprofen. The hybrids are screened for their in vitro inhibition of albumin denaturation, antioxidant, and antitryptic activity. The tested compounds have shown significant results. The lipophilicity was established using both reversed-phase thin layer chromatography and in silico calculations.
Keywords: in vitro, in silico, ibuprofen, nsaids, anti-inflammatory, antitryptic, antioxidant activity
Cite this article: Stanimir P. Manolov, Iliyan I. Ivanov, Dimitar G. Bojilov. IN VITRO AND IN SILICO BIOLOGICAL ACTIVITY OF NEW IBUPROFEN HYBRIDS. Journal of International Scientific Publications: Materials, Methods & Technologies 15, 202-211 (2021). https://www.scientific-publications.net/en/article/1002212/
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