IN VITRO AND IN SILICO BIOLOGICAL ACTIVITY OF NEW IBUPROFEN HYBRIDS
Published: 23 Sep 2021
Abstract: Herein we report the biological evaluation of new hybrids of 1,2,3,4-tetrahydroisoquinoline with ibuprofen. The hybrids are screened for their in vitro inhibition of albumin denaturation, antioxidant, and antitryptic activity. The tested compounds have shown significant results. The lipophilicity was established using both reversed-phase thin layer chromatography and in silico calculations.
Keywords: in vitro, in silico, ibuprofen, nsaids, anti-inflammatory, antitryptic, antioxidant activity
Cite this article: Stanimir P. Manolov, Iliyan I. Ivanov, Dimitar G. Bojilov. IN VITRO AND IN SILICO BIOLOGICAL ACTIVITY OF NEW IBUPROFEN HYBRIDS. Journal of International Scientific Publications: Materials, Methods & Technologies 15, 202-211 (2021). https://www.scientific-publications.net/en/article/1002212/
Download full text
Back to the contents of the volume
© 2021 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/
, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This permission does not cover any third party copyrighted material which may appear in the work requested.