ANTIOXIDANT AND ANTI-CHOLINESTERASE INHIBITION PROPERTIES OF MELISSA OFFICINALIS SUBSP. OFFICINALIS AND LAVANDULA ANGUSTIFOLIA
Fikrican Balcı, Serap Doğan, Mehmet Emin Diken
Pages: 317-324
Published: 16 Nov 2022
Views: 446
Downloads: 44
Abstract: Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) inhibitors are promising compounds for clearing up Alzheimer's disease (AD) symptoms. In this study, extracts of Melissa officinalis L. subsp. officinalis and Lavandula angustifolia L. were prepared with different solvents such as methanol, ethanol and distilled water. It was investigated their inhibitory effects on AChE and BChE enzymes. In addition, antioxidant activities and total phenolic contents of plants were determined using the 1,1-diphenyl-2-picrylhydrazil (DPPH) radical scavenging activity method and Folin- Ciocaltau method, respectively. It has been found that the distilled water extract of M. officinalis subsp. officinalis is the most potent inhibitory of both AChE and BChE enzymes among all of the extracts. IC50 values of the extracts were calculated as 1.65±0.04 mg/mL and 2.33±0.03 mg/mL for AChE and BuChE, respectively. On the other tests, the antioxidant activities of methanol extracts of M. officinalis subsp. officinalis and Lavandula angustifolia plants were 95%, and the highest total phenolic content was observed as 2.30±0.30 g/100g in the methanol extract of M. officinalis subsp. officinalis.
Keywords: acetylcholinesterase, butyrylcholinesterase, melissa officinalis subsp. officinalis and lavandula angustifolia, antioxidant activity
Cite this article: Fikrican Balcı, Serap Doğan, Mehmet Emin Diken. ANTIOXIDANT AND ANTI-CHOLINESTERASE INHIBITION PROPERTIES OF MELISSA OFFICINALIS SUBSP. OFFICINALIS AND LAVANDULA ANGUSTIFOLIA. Journal of International Scientific Publications: Materials, Methods & Technologies 16, 317-324 (2022). https://www.scientific-publications.net/en/article/1002534/
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