NANOTECHNOLOGY AND NANOMATERIALS: USE OF VESICULAR NANOSYSTEMS FOR ISCHEMIC HEART INJURY REPAIR
Rinat A. Mukhamadiyarov, Alexey V. Veremeev, Irina Yu. Zhuravleva
Pages: 392-400
Published: 1 Jan 2012
Views: 55
Abstract: In the present work studied has been the effect of preliminary systemic introduction of liposome preparations of various composition on the contractive activity of the isolated rat heart. Some antioxidants and hight-energy phosphates were introduced into the liposomes. The liposomal preparations were injected via the caudal vien – 15 injections of 25 mg lipid/kg. The intermission made up 48 hours. The hearts were isolated, and total ischemia was reproduced in them. The maximal contractive force was registered; the presents and duration of the perfusate the lactatdegidrigenase activity was determined. It was shown that the liposomes with antioxidants and hight-energy phosphates have a manifested protective effect by ischemia and subsequent reperfusion.
Keywords: liposomes, ischemia, reperfusion
Cite this article: Rinat A. Mukhamadiyarov, Alexey V. Veremeev, Irina Yu. Zhuravleva. NANOTECHNOLOGY AND NANOMATERIALS: USE OF VESICULAR NANOSYSTEMS FOR ISCHEMIC HEART INJURY REPAIR. Journal of International Scientific Publications: Materials, Methods & Technologies 6, 392-400 (2012). https://www.scientific-publications.net/en/article/1003223/
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