IMAGING STUDIES OF TETRA-SULPHONATED PORPHYRIN IN K562 HUMAN CHRONIC MYELOID LEUKEMIA CELLS DURING PHOTODYNAMIC THERAPY
Simona-Florentina Pop, Monica Neagu, Carolina Constantin, Rodica-Mariana Ion
Pages: 42-50
Published: 1 Jan 2011
Views: 89
Abstract: Non-invasive monitoring of molecular targets isparticularly relevant to photodynamic therapy (PDT), including the delivery of photosensitizer in the treatment site and monitoring of molecular and physiological changes following treatment. Photodynamic therapy consists of the uptake of a photosensitizing dye by tumor tissue and subsequent irradiation of the tumor with light of an appropriate wavelength matched to the absorption spectrum of the photosensitizing dye. Singlet oxygen is accepted as the main mediator of photocytotoxicity in photodynamic therapy, causing irreversible cell damage by oxidation and degradation of (intra)cellular biomembrane structures, but with minimal systemic toxicity. This report presents a study of the in vitro non-uniform intracellular distribution of 5, 10, 15, 20 -tetra (4-sulfophenyl) porphyrin (TS PP) on K562 human chronic 4 myeloid leukemia cell line.
Keywords: ts pp, k562 human chronic myeloid leukemia cell line, optical imaging, photodynamic
Cite this article: Simona-Florentina Pop, Monica Neagu, Carolina Constantin, Rodica-Mariana Ion. IMAGING STUDIES OF TETRA-SULPHONATED PORPHYRIN IN K562 HUMAN CHRONIC MYELOID LEUKEMIA CELLS DURING PHOTODYNAMIC THERAPY. Journal of International Scientific Publications: Materials, Methods & Technologies 5, 42-50 (2011). https://www.scientific-publications.net/en/article/1003318/
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