EFFICACY AND TOXICITY OF LEFLUNOMIDE IN PSORIATIC ARTHRITIS (INFLUENCE ON THE CLINICAL ACTIVITY AND LEVEL OF INFLAMMATION AND CONNECTIVE TISSUE DESTRUCTION MARKERS).
Oleg Iaremenko, Dmytro Fedkov, Kateryna Iaremenko, Ganna Mykytenko
Pages: 413-420
Publié: 1 Jan 2013
Vues: 711
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Résumé: Objectives: To determine the features of Leflunomide (LF) use in combination with DMARDs and to evaluate impact of LF on the level of MMP-3 and pyridinoline in adults with psoriatic arthritis (PsA). Methods: 63 PsA pts received LF alone (31 pts) or in addition to Methotrexate or Sulfasalazine (32 pts – COMBI group) were evaluated according to PsARC, PASI50, DAS response criteria, matrix metalloproteinase-3 (MMP-3) and pyridinoline levels before and after 3 months of the treatment. Results: The efficacy in COMBI group was significantly higher on DAS (1.4 times), PASI (2.3 times) and MMP-3 dynamics (1.9 times) vs LF alone. Decrease of MMP-3 and pyridinoline was more striking in PsARC responders vs non-responders (by 28.6% and 10.9% vs 0% and 3.6%). Conclusions: The efficacy of LF COMBI is higher vs LF alone in PsA. Reduction in MMP-3 and pyridinoline shows the ability of LF to lower inflammation and bone destruction levels in pts with PsA.
Mots-clés : leflunomide, psoriatic arthritis, matrix metalloproteinase-3, pyridinoline
Citer cet article : Oleg Iaremenko, Dmytro Fedkov, Kateryna Iaremenko, Ganna Mykytenko. EFFICACY AND TOXICITY OF LEFLUNOMIDE IN PSORIATIC ARTHRITIS (INFLUENCE ON THE CLINICAL ACTIVITY AND LEVEL OF INFLAMMATION AND CONNECTIVE TISSUE DESTRUCTION MARKERS).. Journal of International Scientific Publications: Materials, Methods & Technologies 7, 413-420 (2013). https://www.scientific-publications.net/en/article/1003123/
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