EFFICACY AND TOXICITY OF LEFLUNOMIDE IN PSORIATIC ARTHRITIS (INFLUENCE ON THE CLINICAL ACTIVITY AND LEVEL OF INFLAMMATION AND CONNECTIVE TISSUE DESTRUCTION MARKERS).
Oleg Iaremenko, Dmytro Fedkov, Kateryna Iaremenko, Ganna Mykytenko
Pages: 413-420
Published: 1 Jan 2013
Views: 463
Downloads: 59
Abstract: Objectives: To determine the features of Leflunomide (LF) use in combination with DMARDs and to evaluate impact of LF on the level of MMP-3 and pyridinoline in adults with psoriatic arthritis (PsA). Methods: 63 PsA pts received LF alone (31 pts) or in addition to Methotrexate or Sulfasalazine (32 pts – COMBI group) were evaluated according to PsARC, PASI50, DAS response criteria, matrix metalloproteinase-3 (MMP-3) and pyridinoline levels before and after 3 months of the treatment. Results: The efficacy in COMBI group was significantly higher on DAS (1.4 times), PASI (2.3 times) and MMP-3 dynamics (1.9 times) vs LF alone. Decrease of MMP-3 and pyridinoline was more striking in PsARC responders vs non-responders (by 28.6% and 10.9% vs 0% and 3.6%). Conclusions: The efficacy of LF COMBI is higher vs LF alone in PsA. Reduction in MMP-3 and pyridinoline shows the ability of LF to lower inflammation and bone destruction levels in pts with PsA.
Keywords: leflunomide, psoriatic arthritis, matrix metalloproteinase-3, pyridinoline
Cite this article: Oleg Iaremenko, Dmytro Fedkov, Kateryna Iaremenko, Ganna Mykytenko. EFFICACY AND TOXICITY OF LEFLUNOMIDE IN PSORIATIC ARTHRITIS (INFLUENCE ON THE CLINICAL ACTIVITY AND LEVEL OF INFLAMMATION AND CONNECTIVE TISSUE DESTRUCTION MARKERS).. Journal of International Scientific Publications: Materials, Methods & Technologies 7, 413-420 (2013). https://www.scientific-publications.net/en/article/1003123/
Back to the contents of the volume
© 2026 The Author(s). This is an open access article distributed under the terms of the
Creative Commons Attribution License https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This permission does not cover any third party copyrighted material which may appear in the work requested.
Disclaimer: The Publisher and/or the editor(s) are not responsible for the statements, opinions, and data contained in any published works. These are solely the views of the individual author(s) and contributor(s). The Publisher and/or the editor(s) disclaim any liability for injury to individuals or property arising from the ideas, methods, instructions, or products mentioned in the content.
