EXPLORING THE INTERACTIONS OF IRBESARTAN AND IRBESARTAN–2-HYDROXYPROPYL-Β-CYCLODEXTRIN COMPLEX IN MICELLES
Thomas Mavromoustakos, Dimitrios Ntountaniotis, Georgios Leonis, Eirini Christodoulou
Pagini: 270-278
Publicat: 18 Sep 2019
Vizualizări: 1,792
Descărcări: 184
Citations: 39 (Google Scholar)
Rezumat: Irbesartan is a beneficial drug against hypertension and other diseases. Although it is a polydynamic drug, it suffers from high lipophilicity. New formulations of the drug may increase its efficient pharmacological profile. Towards this aim, we have studied the interactions of irbesartan in simple or complexed form with 2-hydroxypropyl-cyclodextrin in micelles. The interactions of the drug in the two forms in the micelle environment are discussed. Of special interest, is the highly flexibility of the spacer phenyl ring.
Cuvinte cheie: irbesartan, 2-hydroxypropyl-cyclodextrin, sodium dodecyl sulfate, micelles, nmr spectroscopy
Citează acest articol: Thomas Mavromoustakos, Dimitrios Ntountaniotis, Georgios Leonis, Eirini Christodoulou. EXPLORING THE INTERACTIONS OF IRBESARTAN AND IRBESARTAN–2-HYDROXYPROPYL-Β-CYCLODEXTRIN COMPLEX IN MICELLES. Journal of International Scientific Publications: Materials, Methods & Technologies 13, 270-278 (2019). https://www.scientific-publications.net/en/article/1001901/
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