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Materials, Methods & Technologies, Volume 13, 2019

EXPLORING THE INTERACTIONS OF IRBESARTAN AND IRBESARTAN–2-HYDROXYPROPYL-Β-CYCLODEXTRIN COMPLEX IN MICELLES
Thomas Mavromoustakos, Dimitrios Ntountaniotis, Georgios Leonis, Eirini Christodoulou
Pages: 270-278
Published: 18 Sep 2019
Views: 171
Downloads: 38
Abstract: Irbesartan is a beneficial drug against hypertension and other diseases. Although it is a polydynamic drug, it suffers from high lipophilicity. New formulations of the drug may increase its efficient pharmacological profile. Towards this aim, we have studied the interactions of irbesartan in simple or complexed form with 2-hydroxypropyl-cyclodextrin in micelles. The interactions of the drug in the two forms in the micelle environment are discussed. Of special interest, is the highly flexibility of the spacer phenyl ring.
Keywords: irbesartan, 2-hydroxypropyl-cyclodextrin, sodium dodecyl sulfate, micelles, nmr spectroscopy
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