SYNTHESIS OF BIS-HETEROCYCLIC COMPOUNDS BY α-AMIDOALKYLATION REACTION
Stela M. Statkova-Abeghe, Milena B. Staykova, Iliyan I. Ivanov
Pagini: 450-456
Publicat: 1 Jan 2012
Vizualizări: 237
Descărcări: 21
Rezumat: N-acyliminium ions 3, formed in the reaction of benzimidazole and alkyl chloroformates, were successfully used as α-amidoalkylating reagents towards ketoamides 4 a - d. The products 5, obtained in this way, can be further elaborated to bis-heterocyclic compounds. To demonstrate this, product 5 a was transformed to the corresponding amidoalcohol 6 by reduction with NaBH4 in methanol and then it underwent cyclization to the corresponding 2-isoquinolylbenzimidazole 7.
Cuvinte cheie: α-amidoalkylation reaction, ketoamides, bis-heterocyclic compounds, benzimidazole
Citează acest articol: Stela M. Statkova-Abeghe, Milena B. Staykova, Iliyan I. Ivanov. SYNTHESIS OF BIS-HETEROCYCLIC COMPOUNDS BY α-AMIDOALKYLATION REACTION. Journal of International Scientific Publications: Materials, Methods & Technologies 6, 450-456 (2012). https://www.scientific-publications.net/en/article/1003228/
Înapoi la cuprinsul volumului
© 2026 The Author(s). This is an open access article distributed under the terms of the
Creative Commons Attribution License https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This permission does not cover any third party copyrighted material which may appear in the work requested.
Disclaimer: The Publisher and/or the editor(s) are not responsible for the statements, opinions, and data contained in any published works. These are solely the views of the individual author(s) and contributor(s). The Publisher and/or the editor(s) disclaim any liability for injury to individuals or property arising from the ideas, methods, instructions, or products mentioned in the content.
