SYNTHESIS OF BIS-HETEROCYCLIC COMPOUNDS BY α-AMIDOALKYLATION REACTION
Stela M. Statkova-Abeghe, Milena B. Staykova, Iliyan I. Ivanov
Pages: 450-456
Published: 1 Jan 2012
Views: 236
Downloads: 21
Abstract: N-acyliminium ions 3, formed in the reaction of benzimidazole and alkyl chloroformates, were successfully used as α-amidoalkylating reagents towards ketoamides 4 a - d. The products 5, obtained in this way, can be further elaborated to bis-heterocyclic compounds. To demonstrate this, product 5 a was transformed to the corresponding amidoalcohol 6 by reduction with NaBH4 in methanol and then it underwent cyclization to the corresponding 2-isoquinolylbenzimidazole 7.
Keywords: α-amidoalkylation reaction, ketoamides, bis-heterocyclic compounds, benzimidazole
Cite this article: Stela M. Statkova-Abeghe, Milena B. Staykova, Iliyan I. Ivanov. SYNTHESIS OF BIS-HETEROCYCLIC COMPOUNDS BY α-AMIDOALKYLATION REACTION. Journal of International Scientific Publications: Materials, Methods & Technologies 6, 450-456 (2012). https://www.scientific-publications.net/en/article/1003228/
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