ANTIOXIDANT AND ANTI-CHOLINESTERASE INHIBITION PROPERTIES OF MELISSA OFFICINALIS SUBSP. OFFICINALIS AND LAVANDULA ANGUSTIFOLIA
Fikrican Balcı, Serap Doğan, Mehmet Emin Diken
Страницы: 317-324
Опубликовано: 16 Nov 2022
Просмотры: 1,751
Загрузки: 167
Citations: 2 (Google Scholar)
Аннотация: Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) inhibitors are promising compounds for clearing up Alzheimer's disease (AD) symptoms. In this study, extracts of Melissa officinalis L. subsp. officinalis and Lavandula angustifolia L. were prepared with different solvents such as methanol, ethanol and distilled water. It was investigated their inhibitory effects on AChE and BChE enzymes. In addition, antioxidant activities and total phenolic contents of plants were determined using the 1,1-diphenyl-2-picrylhydrazil (DPPH) radical scavenging activity method and Folin- Ciocaltau method, respectively. It has been found that the distilled water extract of M. officinalis subsp. officinalis is the most potent inhibitory of both AChE and BChE enzymes among all of the extracts. IC50 values of the extracts were calculated as 1.65±0.04 mg/mL and 2.33±0.03 mg/mL for AChE and BuChE, respectively. On the other tests, the antioxidant activities of methanol extracts of M. officinalis subsp. officinalis and Lavandula angustifolia plants were 95%, and the highest total phenolic content was observed as 2.30±0.30 g/100g in the methanol extract of M. officinalis subsp. officinalis.
Ключевые слова: acetylcholinesterase, butyrylcholinesterase, melissa officinalis subsp. officinalis and lavandula angustifolia, antioxidant activity
Цитировать эту статью: Fikrican Balcı, Serap Doğan, Mehmet Emin Diken. ANTIOXIDANT AND ANTI-CHOLINESTERASE INHIBITION PROPERTIES OF MELISSA OFFICINALIS SUBSP. OFFICINALIS AND LAVANDULA ANGUSTIFOLIA. Journal of International Scientific Publications: Materials, Methods & Technologies 16, 317-324 (2022). https://www.scientific-publications.net/en/article/1002534/
Вернуться к содержанию тома
© 2026 The Author(s). This is an open access article distributed under the terms of the
Creative Commons Attribution License https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This permission does not cover any third party copyrighted material which may appear in the work requested.
Disclaimer: The Publisher and/or the editor(s) are not responsible for the statements, opinions, and data contained in any published works. These are solely the views of the individual author(s) and contributor(s). The Publisher and/or the editor(s) disclaim any liability for injury to individuals or property arising from the ideas, methods, instructions, or products mentioned in the content.
