SYNTHESIS AND SPECTRAL CHARACTERIZATION OF NEW SALVADORICINE ANALOGUES
Yordan Stremski, Stela Statkova-Abeghe, Iliyan Ivanov, Mladen Naydenov
Pages: 137-143
Published: 6 Sep 2018
Views: 780
Downloads: 164
Abstract: Salvadoricine is an indole alkaloid isolated from the leaves of Salvadora persica Linn. This natural product has interesting and diverse biological profile. An effective one-pot synthesis of Salvadoricine analogues via multicomponent reaction of α-amidoalkylation is proposed. The conditions for the reaction of benzothiazole, alkyl chloroformates and 3-acetylindole were found. The structure of the obtained in good yields analogues of natural alkaloid - Salvadoricine was proved by spectral methods.
Keywords: salvadoricine, benzothiazole derivatives, α-amidoalkylation, multicomponent reactions
Cite this article: Yordan Stremski, Stela Statkova-Abeghe, Iliyan Ivanov, Mladen Naydenov. SYNTHESIS AND SPECTRAL CHARACTERIZATION OF NEW SALVADORICINE ANALOGUES. Journal of International Scientific Publications: Materials, Methods & Technologies 12, 137-143 (2018). https://www.scientific-publications.net/en/article/1001689/
© 2022 The Author(s). This is an open access article distributed under the terms of the
Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This permission does not cover any third party copyrighted material which may appear in the work requested.
