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Materials, Methods & Technologies, Volume 12, 2018

Yordan Stremski, Stela Statkova-Abeghe, Iliyan Ivanov, Mladen Naydenov
Pages: 137-143
Published: 6 Sep 2018
Views: 591
Downloads: 161
Abstract: Salvadoricine is an indole alkaloid isolated from the leaves of Salvadora persica Linn. This natural product has interesting and diverse biological profile. An effective one-pot synthesis of Salvadoricine analogues via multicomponent reaction of α-amidoalkylation is proposed. The conditions for the reaction of benzothiazole, alkyl chloroformates and 3-acetylindole were found. The structure of the obtained in good yields analogues of natural alkaloid - Salvadoricine was proved by spectral methods.
Keywords: salvadoricine, benzothiazole derivatives, α-amidoalkylation, multicomponent reactions
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