EVALUATION OF INTRACELLULAR DISTRIBUTION OF LIPOSOMES USING THE METHODS OF FLUORESCENCE AND CONFOCAL MICROSCOPY
Rinat A. Mukhamadiyrov, Elena A. Velikanova, Igor G. Khaliulin, Maria A. Pautova, Valentina G. Zinchuck, Alexey V. Veremeev, Alexey S. Golovkin
Pages: 234-244
Published: 1 Jan 2013
Views: 237
Downloads: 23
Abstract: This study is aimed at examining luminescence and confocal microscopy potential in determining intracellular localization of luminescent labeled substances incorporated into liposomes. The study shows the data of different experiments on cell cultures and laboratory animals where liposomal labels were used to examine liposome-cell interaction and intracellular distribution of the substances incorporated into liposomes. It was demonstrated that if luminescent labels were chosen adequately it was possible to simultaneously assess the localization of liposomal labels in several subcellular structures. The results of the studies showed the efficacy of luminescence and confocal microscopy for intracellular liposomal substances localization.
Keywords: liposomes, luminescence labeling, intracellular delivery
Cite this article: Rinat A. Mukhamadiyrov, Elena A. Velikanova, Igor G. Khaliulin, Maria A. Pautova, Valentina G. Zinchuck, Alexey V. Veremeev, Alexey S. Golovkin. EVALUATION OF INTRACELLULAR DISTRIBUTION OF LIPOSOMES USING THE METHODS OF FLUORESCENCE AND CONFOCAL MICROSCOPY. Journal of International Scientific Publications: Materials, Methods & Technologies 7, 234-244 (2013). https://www.scientific-publications.net/en/article/1003106/
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