STRUCTURAL ANALOGUES OF THIOFLAVIN T - NEW SYNTHETIC APPROACH
Yordan Stremski, Stela Statkova-Abeghe, Agnes Ivanova, Plamen Angelov, Iliyan Ivanov
Pages: 118-127
Publié: 18 Sep 2019
Vues: 2,301
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Résumé: Thioflavin T (ThT) is a benzothiazolium salt used to visualize and quantify the presence of amyloid plaques found in the brains of chronic neurodegenerative disease patients. Here we propose an effective one-pot approach for the synthesis of six Thioflavin T analogues via amidoalkylation/oxidation/alkylation sequence. The conditions for multicomponent reactions of benzothiazole or thiazole, alkyl chloroformates and N,N-dimethylaniline were studied and optimized.
Mots-clés : thioflavin t, α-amidoalkylation, multicomponent reactions, oxidation, alkylation
Citer cet article : Yordan Stremski, Stela Statkova-Abeghe, Agnes Ivanova, Plamen Angelov, Iliyan Ivanov. STRUCTURAL ANALOGUES OF THIOFLAVIN T - NEW SYNTHETIC APPROACH. Journal of International Scientific Publications: Materials, Methods & Technologies 13, 118-127 (2019). https://www.scientific-publications.net/en/article/1001886/
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