STRUCTURAL ANALOGUES OF THIOFLAVIN T - NEW SYNTHETIC APPROACH
Yordan Stremski, Stela Statkova-Abeghe, Agnes Ivanova, Plamen Angelov, Iliyan Ivanov
Страници: 118-127
Публикувана: 18 Sep 2019
Преглеждания: 2,249
Изтегляния: 261
Резюме: Thioflavin T (ThT) is a benzothiazolium salt used to visualize and quantify the presence of amyloid plaques found in the brains of chronic neurodegenerative disease patients. Here we propose an effective one-pot approach for the synthesis of six Thioflavin T analogues via amidoalkylation/oxidation/alkylation sequence. The conditions for multicomponent reactions of benzothiazole or thiazole, alkyl chloroformates and N,N-dimethylaniline were studied and optimized.
Ключови думи: thioflavin t, α-amidoalkylation, multicomponent reactions, oxidation, alkylation
Цитирайте тази статия: Yordan Stremski, Stela Statkova-Abeghe, Agnes Ivanova, Plamen Angelov, Iliyan Ivanov. STRUCTURAL ANALOGUES OF THIOFLAVIN T - NEW SYNTHETIC APPROACH. Journal of International Scientific Publications: Materials, Methods & Technologies 13, 118-127 (2019). https://www.scientific-publications.net/en/article/1001886/
Обратно към съдържанието на тома
© 2026 The Author(s). This is an open access article distributed under the terms of the
Creative Commons Attribution License https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This permission does not cover any third party copyrighted material which may appear in the work requested.
Disclaimer: The Publisher and/or the editor(s) are not responsible for the statements, opinions, and data contained in any published works. These are solely the views of the individual author(s) and contributor(s). The Publisher and/or the editor(s) disclaim any liability for injury to individuals or property arising from the ideas, methods, instructions, or products mentioned in the content.
