International Scientific Publications
© 2007-2025 Science Events Ltd
Terms of Use  ·  Privacy Policy
Language English French Polish Romanian Bulgarian
Conference room
Materials, Methods & Technologies 2025, 27th International Conference
14-17 August, Burgas, Bulgaria
Call for Papers

Materials, Methods & Technologies, Volume 13, 2019

STRUCTURAL ANALOGUES OF THIOFLAVIN T - NEW SYNTHETIC APPROACH
Yordan Stremski, Stela Statkova-Abeghe, Agnes Ivanova, Plamen Angelov, Iliyan Ivanov
Pages: 118-127
Published: 18 Sep 2019
Views: 1,044
Downloads: 102
Abstract: Thioflavin T (ThT) is a benzothiazolium salt used to visualize and quantify the presence of amyloid plaques found in the brains of chronic neurodegenerative disease patients. Here we propose an effective one-pot approach for the synthesis of six Thioflavin T analogues via amidoalkylation/oxidation/alkylation sequence. The conditions for multicomponent reactions of benzothiazole or thiazole, alkyl chloroformates and N,N-dimethylaniline were studied and optimized.
Keywords: thioflavin t, α-amidoalkylation, multicomponent reactions, oxidation, alkylation
Cite this article: Yordan Stremski, Stela Statkova-Abeghe, Agnes Ivanova, Plamen Angelov, Iliyan Ivanov. STRUCTURAL ANALOGUES OF THIOFLAVIN T - NEW SYNTHETIC APPROACH. Journal of International Scientific Publications: Materials, Methods & Technologies 13, 118-127 (2019). https://www.scientific-publications.net/en/article/1001886/
Back to the contents of the volume

Submit Feedback

We value your input! Use this form to report any concerns or provide feedback on our published articles. All submissions will be kept confidential.

By using this site you agree to our Privacy Policy and Terms of Use. We use cookies, including for analytics, personalisation, and ads.