International Scientific Publications
© 2020 Science Events Ltd
Terms of Use  ·  Privacy Policy
Choose language English French Russian Bulgarian
Conference room
Materials, Methods & Technologies 2020, 22nd International Conference
22-26 June, Burgas, Bulgaria
Call for Papers

Materials, Methods & Technologies, Volume 13, 2019

STRUCTURAL ANALOGUES OF THIOFLAVIN T - NEW SYNTHETIC APPROACH
Yordan Stremski, Stela Statkova-Abeghe, Agnes Ivanova, Plamen Angelov, Iliyan Ivanov
Pages: 118-127
Published: 18 Sep 2019
Views: 156
Downloads: 41
Abstract: Thioflavin T (ThT) is a benzothiazolium salt used to visualize and quantify the presence of amyloid plaques found in the brains of chronic neurodegenerative disease patients. Here we propose an effective one-pot approach for the synthesis of six Thioflavin T analogues via amidoalkylation/oxidation/alkylation sequence. The conditions for multicomponent reactions of benzothiazole or thiazole, alkyl chloroformates and N,N-dimethylaniline were studied and optimized.
Keywords: thioflavin t, α-amidoalkylation, multicomponent reactions, oxidation, alkylation
Download full text

Back to the contents of the volume
By using this site you agree to our Privacy Policy and Terms of Use. We use cookies, including for analytics, personalisation, and ads.