SYNTHESIS AND IN SILICO STUDY OF NEW KETOPROFEN DERIVATIVES
Stanimir P. Manolov, Iliyan I. Ivanov, Valery A. Mollov, Dimitar G. Bojilov
Strony: 250-261
Opublikowano: 18 Sep 2019
Wyświetlenia: 2,243
Pobrania: 156
Streszczenie: Ketoprofen is a widespread non-steroidal anti-inflammatory agent used in treatment of acute pain and chronic arthritis. On the other hand, isoquinoline alkaloids are very well known with their wide range of biological activities. From this point of view it is of interest to us to obtain new isoquinolines containing a ketoprofen residue in their structure as new substances with potential biological activity. To estimate general efficacy and safety of the newly obtained compounds, their biological potential has been evaluated.
Słowa kluczowe: ketoprofen, nsaids, 1,2,3,4-tetrahydroisoquinoline, in silico, α-amidoalkylation reaction, tfoh/sio2, heterogeneous catalysis
Cytowanie artykułu: Stanimir P. Manolov, Iliyan I. Ivanov, Valery A. Mollov, Dimitar G. Bojilov. SYNTHESIS AND IN SILICO STUDY OF NEW KETOPROFEN DERIVATIVES. Journal of International Scientific Publications: Materials, Methods & Technologies 13, 250-261 (2019). https://www.scientific-publications.net/en/article/1001899/
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