SYNTHESIS AND IN SILICO STUDY OF NEW KETOPROFEN DERIVATIVES
Published: 18 Sep 2019
Abstract: Ketoprofen is a widespread non-steroidal anti-inflammatory agent used in treatment of acute pain and chronic arthritis. On the other hand, isoquinoline alkaloids are very well known with their wide range of biological activities. From this point of view it is of interest to us to obtain new isoquinolines containing a ketoprofen residue in their structure as new substances with potential biological activity. To estimate general efficacy and safety of the newly obtained compounds, their biological potential has been evaluated.
Keywords: ketoprofen, nsaids, 1,2,3,4-tetrahydroisoquinoline, in silico, α-amidoalkylation reaction, tfoh/sio2, heterogeneous catalysis
Cite this article: Stanimir P. Manolov, Iliyan I. Ivanov, Valery A. Mollov, Dimitar G. Bojilov. SYNTHESIS AND IN SILICO STUDY OF NEW KETOPROFEN DERIVATIVES. Journal of International Scientific Publications: Materials, Methods & Technologies 13, 250-261 (2019). https://www.scientific-publications.net/en/article/1001899/
Download full text
Back to the contents of the volume
© 2020 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/
, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This permission does not cover any third party copyrighted material which may appear in the work requested.