SYNTHESIS AND IN SILICO STUDY OF NEW KETOPROFEN DERIVATIVES
Stanimir P. Manolov, Iliyan I. Ivanov, Valery A. Mollov, Dimitar G. Bojilov
Pagini: 250-261
Publicat: 18 Sep 2019
Vizualizări: 2,662
Descărcări: 200
Citations: 1 (Google Scholar)
Rezumat: Ketoprofen is a widespread non-steroidal anti-inflammatory agent used in treatment of acute pain and chronic arthritis. On the other hand, isoquinoline alkaloids are very well known with their wide range of biological activities. From this point of view it is of interest to us to obtain new isoquinolines containing a ketoprofen residue in their structure as new substances with potential biological activity. To estimate general efficacy and safety of the newly obtained compounds, their biological potential has been evaluated.
Cuvinte cheie: ketoprofen, nsaids, 1,2,3,4-tetrahydroisoquinoline, in silico, α-amidoalkylation reaction, tfoh/sio2, heterogeneous catalysis
Citează acest articol: Stanimir P. Manolov, Iliyan I. Ivanov, Valery A. Mollov, Dimitar G. Bojilov. SYNTHESIS AND IN SILICO STUDY OF NEW KETOPROFEN DERIVATIVES. Journal of International Scientific Publications: Materials, Methods & Technologies 13, 250-261 (2019). https://www.scientific-publications.net/en/article/1001899/
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