SYNTHESIS AND IN SILICO STUDY OF NEW KETOPROFEN DERIVATIVES
Stanimir P. Manolov, Iliyan I. Ivanov, Valery A. Mollov, Dimitar G. Bojilov
Страницы: 250-261
Опубликовано: 18 Sep 2019
Просмотры: 3,050
Загрузки: 246
Citations: 1 (Google Scholar)
Аннотация: Ketoprofen is a widespread non-steroidal anti-inflammatory agent used in treatment of acute pain and chronic arthritis. On the other hand, isoquinoline alkaloids are very well known with their wide range of biological activities. From this point of view it is of interest to us to obtain new isoquinolines containing a ketoprofen residue in their structure as new substances with potential biological activity. To estimate general efficacy and safety of the newly obtained compounds, their biological potential has been evaluated.
Ключевые слова: ketoprofen, nsaids, 1,2,3,4-tetrahydroisoquinoline, in silico, α-amidoalkylation reaction, tfoh/sio2, heterogeneous catalysis
Цитировать эту статью: Stanimir P. Manolov, Iliyan I. Ivanov, Valery A. Mollov, Dimitar G. Bojilov. SYNTHESIS AND IN SILICO STUDY OF NEW KETOPROFEN DERIVATIVES. Journal of International Scientific Publications: Materials, Methods & Technologies 13, 250-261 (2019). https://www.scientific-publications.net/en/article/1001899/
Вернуться к содержанию тома
© 2026 The Author(s). This is an open access article distributed under the terms of the
Creative Commons Attribution License https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This permission does not cover any third party copyrighted material which may appear in the work requested.
Disclaimer: The Publisher and/or the editor(s) are not responsible for the statements, opinions, and data contained in any published works. These are solely the views of the individual author(s) and contributor(s). The Publisher and/or the editor(s) disclaim any liability for injury to individuals or property arising from the ideas, methods, instructions, or products mentioned in the content.
